On the western edge of the region is the Umbrian section of the Autostrada del Sole (A1), Italy's principal north–south highway. It links Florence and Rome with Orvieto and passes near Todi and Terni. The S3 intersects with the A1 and leads on to Assisi and Urbino. The Adriatica superhighway (A14) runs north–south along the coast, linking the Marches to Bologna and Venice.
The steep hills and deep valleys that make Umbria and the Marches so idyllic also make for challenging driving. Fortunately, the area has an excellent, modern road network, but be prepared for tortuous mountain roads if your explorations take you off the beaten track. Central Umbria is served by a major highway, the S75bis, which passes along the shore of Lake Trasimeno and ends in Perugia. Assisi is served by the modern highway S75; the S75 connects to the S3 and S3bis, which cover the heart of the region. Major inland routes connect coastal A14 to large towns in the Marches, but inland secondary roads in mountain areas can be winding and narrow.