Yangon is not difficult to navigate on foot, as most of downtown is laid out on a grid and the area where tourists explore is quite compact. Addresses are easily recognizable, and it's simple to ask for directions. The area of Yangon that's the easiest to navigate is that which surrounds the Bogyoke Market, from Bogyoke Aung San Road south to The Strand, and from Aung Yadana Street east to May Yu Road. Be careful walking around at night. Crime is not the issue—Myanmar is extremely safe—but many streets have large holes in the sidewalks and no street lamps.
The farther-flung areas can be reached without hassle by taxi or rickshaw. A fast-paced traveler could cover the best of Yangon in two days.