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SC to Cape Code

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Hi!
I am new to Fodor's and excited about the help I might get for a trip I'm taking the 2nd week in August. I have been asked to drive 3 senior adult ladies from Florence, SC to Cape Cod/Martha's Vineyard. I would like suggestions on the best route(s) that would include bypassing NYC. I just have a fear of driving through that city even though I've never done it. I would greatly appreciate any suggestions on routes and/or places of interest, places to stay, and places to eat while there. Thank you so very much!

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