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Rail or Bus Travel in Italy

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We are arriving in Rome- Fiumicino on the 25th of September and staying at the NH Giustiniano Hotel. Address: Via Virgilio 1 E/f/g, Rome. What would be the best way to reach our hotel?

We are then leaving Rome on the 28th to Siena. Bus or train?

We are then leaving Siena on the 3rd to Lucca Best way to travel?

Finally we are leaving Lucca on the 9th and traveling to Venice for our final destination. Best way to travel?

Would love to take a train, but most important is the convenience. Will have multiple suitcases for shopping and clothes. This is our trip of a lifetime and would love to take it all in.

Thank you for any comments, it is greatly appreciated. First time in Europe.

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