I'm another who has no complaints about the buses in Andalusia (although I've never taken one that long) but if you decide to take the train - and aren't already visiting there - perhaps consider breaking the journey in Cordoba. We really like it there.

I took an ALSA bus from Seville to Granada, in March 2022. The trip worked ok. The driver stopped at a gas station and let himself out but he forgot to keep the bus door unlocked so that we could get out too. The bus did have a bathroom. I used it once without a problem.

Appreciate all the responses.

I've just booked the 13:18 train. We don't have to check out of our accommodation until noon, so the timing works okay. The thought of being on a bus for 4.5 hours without a bathroom...well. I know some buses have loos, but evidently not all, and I'm not sure I trust that the bus we book is the bus we'll get based on many reviews. Taking the train puts us in Madrid just a few hours later than the bus would have, and decreases the journey by an hour. We can't accomplish much on a travel day anyway, so not a big deal.

dreamon - we might take a day trip to Cordoba from Seville - only 40+ minutes from there.

This trip has come and gone. We took the Alsa bus from Seville to Granada, and the train on our other routes.

Hello there I know your trip has come and gone.
In a nutshell how did it work for you to take the bus?

It worked great amsdon. We had one small hitch - our bus had some minor motor issue prior to departure, but it was quickly replaced with another one, so no worries.

I'd do it again in a heartbeat - in fact, the bus was nicer than a few of the trains.

Thank you !

Hi amsdon,
I have taken many Alsa buses, as has mikelg, and especially the trip from Sevilla to Granada (or vice versa) is absolutely fine, as the departures times are more frequent, more convenient, than the trains. As mikelg often reminds us,
the Spain bus system is not your American Greyhound. The buses are clean, comfortable, modern, cheap, efficient, on time and widely used by Spaniards (and by us).

Thank you Maribel.
There are several sections in Our much anticipated trip that will likely be including buses, and perhaps a train or 2. . 🙂 I've been here Is lurking and reading New and also the old posts.
I guess I'll post my general itinerary soon.