Ladera is an Oprah favorite and was #1 in the world on the Conde Nast magazine's reader list for top hotels.

The british Virgin islands namely Virgin Gorda has a wide selection of private owned villas...I agree that once you have gone to a villa you will never go back to a hotel. so do some research....or you can have your own private island.....Necker Island, if you are truly high end

Firefly or Cotton House , Musyique .... ( diana also suggested it 1 )

Oops ! Mustique ....