Hotel 50 Bowery
With a design aesthetic and food offerings inspired by the neighborhood's multifaceted heritage, this thoroughly modern hotel from Hyatt's Joie de Vivre group takes full advantage of its downtown location. Street-art-style paintings; a year-round rooftop bar (the Crown); and a permanent exhibition curated by the nearby Museum of Chinese in America make this a standout in an area of town that tends to lack in quality accommodations.