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Manu Expeditions. These Cusco-based specialists in bird watching and nature tours offer decades of experience in trips deep into the rain forest of the Manu Biosphere Reserve. Trips last anywhere from five to nine days and include overnights at several remote nature lodges. 084/225–990. www.manuexpeditions.com. From $1,835.
Pantiacolla. Pantiacolla organizes three- to nine-day eco-tours to Manu with overnights at some or all the company's four lodges: the Posada San Pedro, Pantiacolla Lodge, Yine Lodge, and Sachavaca Campsite. Tours range from two nights in the cloud forest to a nine-day expedition into Manu's reserved zone, where travelers may see macaws, various monkey species, and with luck, a jaguar or giant otter. The lodges are more rustic than the competition, but the guides are excellent and the tours are much less expensive. 084/238–323. www.pantiacolla.com. From $410.
Rainforest Expeditions. The Tambopata experts, Rainforest Expeditions runs three- to seven-day nature tours deep into the Tambopata National Reserve, with accomodations at one or more of the company's three lodges: the Posada Amazonas, Refugio Amazonas, and Tambopata Research Center. Av. Larco 1116, 4to Piso, Miraflores, Lima. 01/719–6422; 877/231–9251 in U.S. & Canada. www.perunature.com. From $432.
Dawn on the Amazon. Dawn on the Amazon can arrange day tours in and around Iquitos. Maldonado 185, Iquitos. 065/223–730. www.dawnontheamazon.com. From $85.
Amazonia Expeditions. Amazonia Expeditions runs trips to the Reserva Comunal Tamshiyacu-Tahuayo, one of the most biologically diverse protected areas in the world. Trips include private guides, regular wildlife sightings, and stays at the company's two lodges: the Tahuayo Lodge and the Tahuayo River Amazon Research Center. Part of the profits are used to support conservation, scientific research, and improvement of life in the reserve's remote communities. 800/262–9669 in U.S. www.perujungle.com. From $895.
Aqua Expeditions. Aqua Expeditions runs high-end nature cruises along the upper Amazon between Nauta and the Pacaya Samiria Reserve, where tributaries and lakes are explored in small boats. Cruises last for three, four, or seven nights. 01/434–5544; 866/603–3687 U.S. & Canada. www.aquaexpeditions.com. From $2,850.
Delfin. Delfin offers three- and four-night Amazon eco-cruises on two boats: the luxurious Delfin I, which takes eight passengers, and the larger Delfin II, which sleeps 28. Passengers board small boats each day for trips up Amazon tributaries. 01/719–0998. www.delfinamazoncruises.com. From $2,360.
Explorama Tours. Explorama Tours offers trips down the Amazon River lasting anywhere from three to seven days, with stays at its rustic Explorama and ExplorNapo nature lodges or the more comfortable Ceiba Tops Lodge. 065/252–530; 800/707–5275 U.S. & Canada. www.explorama.com. From $340.
Green Tracks. Green Tracks is a U.S.-based company that organizes one-week river expeditions up the Amazon to the Pacaya Samiria Reserve, and books stays at the best nature lodges in the Iquitos and Puerto Maldonado areas. 800/892–1035 or 970/884–6107. www.greentracks.com. From $1,530.