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The logistics of travel and isolation make it difficult to visit both the northern and southern Amazon regions—separated by 600 km (370 miles) at their nearest point—during one trip to Peru. The city of Iquitos is the jumping-off point for the northern Amazon; Puerto Maldonado for the southern Amazon tributaries the Madre de Dios and Tambopata rivers. Some 1,200 km (740 miles) and connecting flights back in Lima separate the two cities. The Manu Biosphere Reserve, on the upper Madre de Dios River, is primarily reached by land and river from Cusco. Both the northern and southern regions are dotted with excellent jungle lodges, whereas the Peruvian Amazon can also be experienced on a cruise.