By Air to Iquitos: Aero Condor flies to Iquitos daily and also to Cusco and Puerto Maldonado from Lima. LanPeru and STAR Peru also fly to Iquitos. Iquitos's Aeropuerto Internacional Francisco Secada Vignetta is 8 km (5 mi) from the city center. A taxi to the airport should cost around S/10.
By Air to Madre de Dios: Starting in Lima and stopping in Cusco, Aero Condor and LanPeru have daily or weekly flights to Aeropuerto Padre Aldámiz (PEM), 5 km (3 mi) from Puerto Maldonado. Several Manu lodges fly their passengers to the small airstrip at Boca Manu on a charter basis.
By Road: A long, rough jungle road to Puerto Maldonado from Cusco is a grueling two- to three-day truck ride. The overland trip from Cusco to Manu, 12 hours over rugged terrain, is via a road called the Carretera a Shintuya, which plunges spectacularly from the páramo (highlands) into the cloud forests at Atalaya. Here or at Shintuya, farther down the river, you take a boat along the Alto Madre de Dios River.