If you arrive in Cusco with the intention of hopping on the train to Machu Picchu the next morning, you'll probably only have time to take a stroll though the Plaza de Armas and visit Qorikancha (Temple of the Sun) and the Catedral. However, we recommend spending at least two days in Cusco before venturing off to Machu Picchu, giving yourself time to acclimate to the altitude and get to know this city of terra-cotta roofs and cobblestone streets. The churches close for a few hours in the middle of the day. Most of the city's museums close on Sunday.
Cusco takes its newest role as tourist favorite in stride, and absorbs thousands of travelers with an ample supply of lodgings, restaurants, and services. That a polished infrastructure exists in such a remote, high-elevation locale is a pleasant surprise.
Take it easy! Cusco is a breathless 3,300 meters (10,825 feet) above sea level—a fact you'll very soon appreciate as you huff and puff your way up its steep cobbled streets. With 30% less oxygen in the atmosphere, the best way to avoid altitude sickness is to take it easy on your first few days. There's no point in dashing off on that Inca hike if you're not acclimatized—altitude sickness is uncomfortable at best and can be very dangerous.
Locals swear by mate de coca, an herbal tea brewed from coca leaves that helps with altitude acclimatization. Indigenous peoples have chewed the leaves of the coca plant for centuries to cope with Andean elevations. But the brewing of the leaves in an herbal tea is considered a more refined and completely legal way to ingest the substance, in Andean nations at least. Most restaurants and many hotels have a pot steeping constantly.
Cusco's Aeropuerto Internacional Teniente Alejandro Velasco Astete (CUZ) is about 15 minutes from the center of town. An army of taxis waits at the exit from baggage claim, and charge S/5 to take you to the city center.
Cusco's center city is most enjoyably explored on foot. Many of the streets open to vehicular traffic are so narrow that it's simply faster to walk. Cusco streets have a habit of changing names every few blocks, or even every block. Many streets bear a common Spanish name that everyone uses, but have newly designated street signs with an old Quechua name in order to highlight the city's Inca heritage: the Plaza de Armas is Haukaypata, the Plaza Regocijo is Kusipata, Triunfo is Sunturwasi, Loreto is Intikijlli, Arequipa is Q'aphchijk'ijllu, and intermittent blocks of Avenida El Sol are labeled Mut'uchaka. And so on.