The trip from Quito to Lago Agrio takes eight hours by bus. Since Lago Agrio is near the Colombian border, it's best to consult a tour operator about safety in this area. The trip from Quito to Coca takes nine hours. A journey from Cuenca to Macas takes 10-12 hours, but the road is frequently impassable, a condition that comes and goes with the weather. Since El Oriente has no truly dry season, don't count on being able to negotiate this route overland.