You will need a car to tour northwest Wyoming; to reach the really spectacular backcountry a four-wheel-drive vehicle is best. Major routes through the area include U.S. 191, which runs north-south through Jackson, on the western edge of the state, and U.S. 26/287, which runs east of Grand Teton National Park (also on the western edge of the state, within the Jackson Hole valley) toward Dubois. Much of the driving you do here will take you through the mountains—including the Absaroka and Wind River ranges that dominate the region.