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I-80 is the major artery through this region, running from Cheyenne at the southeast corner of the state west to Evanston in the southwest corner of the state.
Once you explore this region, it becomes apparent why Wyoming has earned the nickname the "Cowboy State." The plains remain a prime grazing spot for wild horses, cattle, and sheep. As you drive west, the plains give way to the snowcapped mountains of the appropriately named Snowy Range. After a few more hours driving west you'll reach the Red Desert, with unique rock formations and herds of wild horses and pronghorn.