13 Best Sights in The Midlands and Upstate, South Carolina

This attractive, expansive gallery contains art from the Kress Foundation collection of Renaissance and baroque treasures, sculpture, and decorative arts. There are prominent paintings by European and American masters, including a Monet and a Botticelli, as well as temporary exhibitions featuring world-famous works by artists like Salvador Dalí and M. C. Escher.

South Carolina's only national park is unlike any other—the park is the floodplain of the Congaree River, meaning that throughout the year, the majority of this bottomland forest is a true swamp. The wettest, hardest-to-reach areas survived centuries of logging, leaving towering cypress trees—some of the oldest and largest trees east of the Mississippi River—in the heart of the 27,000-acre park. Access varies by your ambition and tolerance for mud. A 2.6-mile loop via elevated boardwalk is handicap accessible and meanders through perennial swamp, higher pine uplands, and past Weston Lake. Longer trails total 22 miles, allowing for loops and overnight treks into the park, but bring extra socks and boots suitable for wading, especially on the fantastic but especially soggy Oakridge Trail. A potentially drier method of exploring the interior is by kayak or canoe. Local outfitters, including River Runner Outdoor Center and Carolina Outdoor Adventures, run three-hour kayak tours from the Cedar Creek Canoe Access. Or, coordinate a shuttle and canoe rental and paddle Cedar Creek one way, putting in at Bannister Bridge Canoe Access.

Bring binoculars and sharp ears—Congaree hosts a cacophony of birds and wildlife, including otters, wild boar, deer, and woodpeckers. The park also has two primitive campgrounds. Book in advance, especially during the two-week synchronized firefly season in May and June.

Apart from packaged snacks at the visitor center, there are no concessions in the park, and nearby restaurants are limited.

This top-notch zoo contains more than 2,000 animals and birds in natural habitats, including a sea lion exhibit and western lowland gorillas. Walk through landscaped gardens to see elephants, Siberian tigers, koalas, and penguins. The South American primate collection has won international acclaim, and the park is noted for its success in breeding endangered species. The Aquarium Reptile Complex has regional, desert, tropical, and marine specimens. Ride the carousel, and take a tram over the Saluda River to the 70-acre botanical gardens. A forested section with walking trails has spectacular views of the river and passes Civil War ruins. Stop by the Saluda Factory Interpretive Center for more information about the site's history and its connection to the Civil War.

With more than 90,000 square feet for climbing, exploring, painting, playing, building—oh, and learning, too—this museum is a full day of hands-on fun. Eddie, a 40-foot-tall statue of a boy that can be climbed on (and in) by children and adults, is the centerpiece. Each of nine galleries has a theme, such as My Backyard, Wags & Whiskers, and Maker Works. Kids can shop in their own grocery store, act as firefighters in a full-size fire truck, and pretend to be newscasters.

Dating from 1818, this grand home is filled with lavish furnishings collected by three generations of two influential families. The mansion was rehabilitated and outfitted with new interactive exhibits and expanded gardens to celebrate its 200th anniversary in 2018. Buy tickets at the Robert Mills House.

This cottage and outdoor museum was the home of Celia Mann, one of only 200 free African Americans in Columbia in the mid-1800s. Buy tickets at the Robert Mills House.

Where the Broad and Saluda Rivers form the Congaree River is the site of the city's original waterworks and hydroelectric plant. Interpretive markers describe the area's plant and animal life and tell the history of the buildings. A 2½-mile paved trail weaves between the river and the canal and is filled with runners and walkers.

The classic, columned 1823 house was named for its architect, who later designed the Washington Monument. It has opulent Regency furniture, marble mantels, and spacious grounds. This is the home of the Historic Columbia Foundation, where you can get walking and driving tour maps of historic districts and buy tickets to other historic homes.

Exhibits in this refurbished textile mill explore the state's natural history, archaeology, and historical development. An iron gate made for the museum by Philip Simmons, the "dean of Charleston blacksmiths," is on display, as is an exhibit on South Carolina's astronauts and artifacts associated with the state's cotton industry and slavery. Newer exhibits are geared toward the younger set, including a 4-D theater and nature-oriented rotating films shown in the planetarium.

When skies are clear, the observatory stays open until 8 on Tuesday.

Six bronze stars on the western wall of South Carolina's grandest building mark where direct hits were made by General Sherman's cannons. Begun in 1851 and completed in 1907, the capitol is made of native blue granite in the Italian Renaissance style. The interior is richly appointed with brass, marble, mahogany, and artwork. Guided tours are available throughout the day.

This glowing optical illusion painted on the wall of the Federal Land Bank Building in 1976 by local artist Blue Sky gives the appearance of a tunnel leading to the mountains. To celebrate the mural's 25th anniversary in 2001, the city hired Blue Sky to create another work in the same parking lot: the world's largest fire hydrant towers 40 feet here.

A highlight of this sprawling university is its original campus, founded in 1801. Stroll the historic buildings and gardens of the Horseshoe, or dive into the special collections at the South Caroliniana Library, built in 1840 as the first stand-alone college library in the nation. The McKissick Museum on campus features exhibits on geology, gemstones, and local folklife.

This boyhood home of President Woodrow Wilson displays the gaslights, arched doorways, and ornate furnishings of the Victorian period. Museum exhibits explore the life of the president and the South in the 1870s.

Buy tickets at the Robert Mills House, where you get a discount if you plan to visit more than one historic home.