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The coast-to-coast Interstate 40 runs east–west through Asheville. Interstate 26 runs from Charleston, South Carolina, to Asheville and, partly on a temporary route, continues northwest into Tennessee and the Ohio Valley. Interstate 240 forms a perimeter around the city. U.S. 19/23 is a major north and west route. The Blue Ridge Parkway runs northeast from Great Smoky Mountains National Park to Shenandoah National Park in Virginia, passing Cherokee, Asheville, and the High Country. U.S. 221 runs north to the Virginia border through Blowing Rock and Boone and intersects Interstate 40 at Marion. U.S. 321 intersects Interstate 40 at Hickory and heads to Blowing Rock and Boone.