The Santa Fe Trail

In the mid-19th century, this vast tract of grasslands and prairies, along with the eastern foothills of the Sangre de Cristo range, became the gateway to New Mexico for American settlers headed here from the Midwest. Towns along the Santa Fe Trail's modern offspring, Interstate 25—notably Las Vegas but also Raton up near the Colorado border—remain popular stops for road-tripping fans of Old West history.

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Fodor's Essential Southwest: The Best of Arizona, Colorado, New Mexico, Nevada, and Utah

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