Vacationing families and businesspeople who want luxury pick this sprawling resort complex that towers over the island-studded San Carlos Bay at the last mainland exit before the Sanibel Causeway. Choose from two lodging options—a concierge club–style inn and the hotel—most rooms with sweeping bay views. There's also tennis, the best resort spa in the Fort Myers area, restaurants (one of which is a buffet-dining yacht), the gorgeous circular windowed Charley's Bar, and a large free-form pool, among other facilities and activities. Rent a kayak, Jet Ski, or pontoon boat; take a wildlife-viewing cruise; or go fishing. The beach is small and bay-side, but Sanibel's gorgeous stretches of sand are a quick ride away.