A scenic drive east of the Silverado Trail winds past Lake Hennessey to Nichelini, the Napa Valley's oldest continuously operated family-owned winery. Erected in the late 1800s by Anton Nichelini, an Italian-Swiss immigrant, the old winery buildings, still in use, cling to a steep embankment where the road skirts a cliff. The wines to taste—they're made by Anton's great-great-granddaughter Aimée Sunseri—are the Zinfandel, its Italian cousin the Primitivo, the Cabernet Sauvignon, the Petite Sirah, and the extra-crisp old-vine Muscadelle. The last grape often finds its way into white Bordeaux blends, but here it makes a single-varietal wine redolent of tropical fruit. The winery is open for drop-in tastings on Fridays and weekends, the rest of the week by easily made appointments.