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June and July bring near-constant sun (nothing quite like walking out of a restaurant at 11 pm into broad daylight), sometimes punctuated by afternoon cloudbursts. In winter it gets so cold (−30°F or below) that boiling water flung out a window can land as ice particles.
Like most of Alaska, many of the Interior's main attractions are seasonal, May into mid-September. A trip in May avoids the rush, but it can snow in Fairbanks in spring. Late August brings fall colors, ripe berries, active wildlife, and the start of northern lights season, with marvelous shows, if you hit the right night. Winter-sports fans should come in March, when the sun's back but there's still plenty of snow.