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The park is 120 miles south of Fairbanks, or 240 miles north of Anchorage, on the George Parks Highway, which is the most common access route.
There is a second, seldom-used road to the park: the Denali Highway leads from Paxon, which is accessible from the Richardson Highway (which connects Fairbanks and Valdez) to Cantwell, coming out just south of the park entrance. This 134-mile road is mostly unpaved, with few services. Only people with high-clearance cars should try it. The Denali Highway is closed in winter.