If you have to spend a night in Colón, this is your best option, since it's next to the Colón 2000 cruise port, with its shops and restaurants, in one of the safest parts of town. The rooms are pretty standard, but well equipped; be sure to get a port view. The lobby has a large restaurant and a lounge, and there are several more dining options next door. Most of your fellow guests will likely be Latin American business travelers, who have come to make wholesale Free Zone purchases. All in all, it's a safe, dependable hotel with a good business center and buffet breakfasts.
Paseo Gorgas, Calle 13, Colón, 0301, Panama
507-446–2000; 800-830–5222-in the U.S. and Canada