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Padafont has hourly buses between Panama City's Albrook Terminal and David from 6 am to 8 pm and direct buses at 10:45 pm and midnight. The trip takes about eight hours, with a meal stop in Santiago. Small buses to Boquete, Volcán, Cerro Punta, and Paso Canoas (the border post with Costa Rica) depart every 30 minutes during the day.
Terminal de Buses (Av. del Estudiante, one block east of Av. Obaldía, David.)