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While Guadalajara is a relatively safe place, it still has crime, like all major cities. The best advice? Be aware of your surroundings at all times. If possible, avoid ATMs at night and be watchful of anyone following you from a bank. Try not to walk around alone at night. And, if possible, attempt to get taxis from a sitio (taxi stand) rather than flagging them down on the street.
While the H1N1 virus is thought to have developed in Mexico City, you are no more at risk of catching the virus in Mexico than in the United States. Take normal precautions like washing your hands and avoiding touching your face. You'll see antiseptic hand gel placed in key locations across Guadalajara, including in malls, restaurants and tourist attractions. Guadalajara has experienced a growing number of dengue fever cases, a virus contracted from mosquitoes that has seen an increasing number of outbreaks in many Latin and South American countries. The best protection is to wear long sleeves and pants during cooler times, and to use insect repellent containing DEET.
Despite having only a quarter of the capital's traffic, Guadalajara regularly gives it a run for its money as Mexico's most polluted city. Air quality readings reach unsatisfactory levels during the winter months, starting in October and continuing until the winds pick up in February. The pollution can cause raw throats, sore eyes, and sinus irritation.