At the end of Calle Santander, this excellent hotel—there's a branch by the same name in Antigua, and a stay at both branches in one trip gets you a 10-percent discount on the rates—has some of the best views of the lake. The rooms make use of handwoven fabrics from the local communities. Ask for one of the newer beachfront rooms with slightly more modern amenities and better views. Relax by the pool or in one of the hammocks hung along a breezy corridor. There's a small on-site museum that gives insight into the history of the Maya.
End of Calle Santander, Panajachel, 07010, Guatemala