Iberia has the most flights to this part of Spain. However, if you are arriving from the United States, it may be more economical for you to fly to London and then catch one of the no-frills flights on airlines like easyJet and Ryanair, which have frequent flights to Alicante. There are three airports serving the region: Valencia, Alicante, and San Javier (for Mar Menor and Murcia).
If you're traveling here from other parts of Spain, catching a bus is a reliable option., although few travelers use the service, preferring trips organized by local travel agencies and hotels. Private companies run buses down the coast and from Madrid to Valencia, Benidorm, and Alicante. Bus travel is generally inexpensive and comfortable.
Arriving by train lands you in Alicante, which has two train stations: the main Estación de Madrid and the local Estación de la Marina, from where the local FGV line (not affiliated with RENFE) runs along the Costa Blanca from Alicante to Denia. The Estación de la Marina is at the far end of Playa Postiguet and can be reached by buses C1 and C2 from downtown.
The autopista (toll highway) A7 runs from Barcelona through Valencia and Alicante as far as Murcia, with the A37 branching off just south of Elche to Cartagena. Toll roads, though costly (EUR 2-EUR 30), are often worth it for the time saved and the safer conditions. Paying with a credit card is an easy option. The other main links with the region are the A3 from Madrid to Valencia and the N111/A31 from Madrid to Murcia via Albacete. The N332 offers a nontoll (but slower) alternative down the coast from Valencia to Águilas, but between Denia and Calpe the road takes you through small villages with numerous stop lights and it's necessary to take even smaller, slower roads if you want to be near the sea.