Emergency numbers are accessible from every phone, including cellular phones, all over Italy. If you have ongoing medical concerns, it's a good idea to make sure someone is on duty all night where you're staying -- not a given in Umbria, less so in the Marches. As elsewhere in Italy, every pharmacy in Umbria and the Marches bears a sign at the door listing area pharmacies open in off-hours. Perugia, Spoleto, Assisi, Gubbio, and Urbino all have at least one so-called "night" pharmacy, but out in the countryside you may need a car to get to one. Try to bring extras with you of all medications you take regularly.
In car emergencies, call ACI for towing and repairs -- you can ask to be transferred to an English-speaking operator; be prepared to tell the operator which road you're on, the direction you're going (e.g., "verso [in the direction of Perugia") and the targa (license plate number) of your car. The great majority of Italians carry cellular phones, so if you don't have one, for help, flag down someone who does.
ACI (803/116). Ambulance (118). Carabinieri (Military Police. 112). Emergencies (113). Fire (115).