The two great Umbrian artists hold sway in this 16th century basilica. Pinturicchio's vivid frescoes in the Cappella Baglioni (1501) are striking for their rich colors, finely dressed figures, and complex symbolism. Among Pinturicchio's finest works are the Nativity, Christ Among the Doctors (on the far left side is a portrait of Troilo Baglioni, the prior who commissioned the work), and the Annunciation (look for Pinturicchio's self-portrait in the Virgin's
room). The artist painted them after he had already won great acclaim for his work in the Palazzi Vaticani in Rome for Borgia Pope Alexander VI. Two pillars on either side of the apse are decorated with frescoes by Perugino (circa 1450–1523).