Housed in part of the original cathedral structure, this nine-room museum houses an impressive number of large, splendid paintings by native son Luca Signorelli (1445–1523), as well as a beautiful Annunciation by Fra Angelico (1387/1400–1455), which is a delightful surprise in this small town. The former oratory of the Compagnia del Gesù, reached by descending the 1633 staircase opposite the Duomo, is part of the museum. The church was built between 1498 and
1505 and restructured by Giorgio Vasari in 1543. Frescoes depicting sacrifices from the Old Testament by Doceno (1508–56), based on designs by Vasari, line the walls.
Piazza Duomo 1, Cortona, 52044, Italy