This 18th-century baroque cathedral has a single nave with chapels and paintings on the sides. There are two altarpieces by local artist Francesco Zuccarelli (1702–88), a rococo landscape artist, favorite of George III, and one of the founders of the British Royal Academy.
- Address: Piazza S. Gregorio 1, Pitigliano, 58017
- Phone: 0564/616090
- Hours: Daily 9–7
- Location: Pitigliano