SENA connects Rome with Siena on several scheduled daily trips. When traveling to Tuscany from elsewhere in Italy, the train is almost always a better option than the bus; buses are subject to the vagaries of road traffic, and the seats are narrow and cramped.
CPT (Compagnia Pisana Trasporti, Piazza Sant'Antonio 1, Pisa. 050/505511. www.cpt.pisa.it). SENA (Piazza Gramsci, Siena. 0577/283203. 0577/40731. www.sena.it).