One of the region's most famous residences, this patrician villa halfway between Frascati and Grottaferrata is now a first-class hotel, though the standard-issue guest rooms are a bit of a letdown amid the frescoed salons. Modeled after Rome's Villa Farnesina, the 1580 house was owned over the centuries by the regal Borghese and Odelscalchi families, and was nearly destroyed by bombs in World War II. The vast reception rooms on the main floor—covered with frescoes of landscapes, mythological figures, and garden scenes by eminent 17th-century painters—survived mostly unscathed. The showpiece remains the South Gallery, frescoed by Giovanni Paolo Pannini in a swirl of trompe-l'oeil scenes, a masterpiece of baroque decorative art. By contrast, the guest rooms tend to be plain, with white walls and traditional furniture; but you can opt to stay in the newly refurbished Garden Rooms in the adjacent former Limonaia, connected by an underground passage to the main building. The elegant Acquaviva restaurant transforms into an alfresco dining venue in summer, with tables laid out on the terrace overlooking the Roman countryside.