Housed in this late-15th-century Catalan Gothic palace with Renaissance elements is the Galleria Regionale. Among its treasures are the Annunciation (1474), a painting by Sicily's prominent Renaissance master Antonello da Messina (1430–79), and an arresting fresco by an unknown 15th-century painter, titled The Triumph of Death, a macabre depiction of the plague years. Call before you visit to make sure that they're open.
Via Alloro 4, Palermo, 90133, Italy
091-6230011; 091-6230047-for tickets