Santa Prisca. Off the beaten path, this clean and comfortable hotel has been welcoming guests for more than 50 years. Though the exterior looks like nothing more than your average Roman apartment building, once inside you'll find that rooms are spacious—if you're lucky, you'll get one with a cute little balcony. The area itself offers plenty of parking, and the advantage of being so close to Testaccio is the abundance of great lounges, pizzerias, and nightlife.
Pros: near public transportation (trams and Metro); complimentary Wi-Fi; outside terrace with chairs and tables for relaxing. Cons: some say breakfast is mediocre; the school next door can be a little noisy on weekdays.