One of the Centro Storico's defining sites, this octagonal church was built around the corner from the Duomo for a charitable institution seven noblemen founded in 1601. The institution's aim was to carry out acts of Christian charity like feeding the hungry, clothing the poor, nursing the sick, sheltering pilgrims, visiting prisoners, and burying the indigent dead—acts immortalized in the history of art by Caravaggio's famous altarpiece depicting the Sette Opere della Misericordia (Seven Acts of Mercy). In this haunting work, the artist has brought the Virgin, borne atop the shoulders of two angels, down into the streets of Spaccanapoli, populated by figures in whose spontaneous and passionate movements the people could see themselves. The original church was considered too small and was destroyed in 1658 to make way for a new church that was designed by Antonio Picchiatti and built between 1658 and 1672. Pride of place is given to the great Caravaggio above the altar,
but there are other important Baroque-era paintings on view here. Some hang in the church—among them seven other works of mercy depicted individually by Caravaggio acolytes—while other works, including a wonderful self-portrait by Luca Giordano, are in the adjoining pinacoteca (picture gallery). Step into the choral chamber for a bird's-eye view of the Sette Opere della Misericordia.