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Dedicated to patron saint Pantaleone, the cathedral was founded in 1086 by Orso Papiro, the town's first bishop. Rebuilt in the 12th and 17th centuries, it retains traces of medieval frescoes in the transept, an original mullioned window, a marble portal, and a three-story 13th-century bell tower playfully interwoven with mullioned windows and arches. The 12th-century bronze door has 54 embossed panels depicting Christ's life, and saints, prophets, plants, and animals, all narrating biblical lore. The nave's three aisles are divided by ancient columns, and treasures include sarcophagi from Roman times and paintings by southern Renaissance artist Andrea da Salerno. Most impressive are the two medieval pulpits: the earlier one (on your left as you face the altar), used for reading the Epistles, is inset with a mosaic scene of Jonah and the whale, symbolizing death and redemption. The more famous one opposite, used for reading the Gospels, was commissioned by Nicola Rufolo in 1272 and created by Niccolò di Bartolomeo da Foggia. It seems almost Tuscan in style, with exquisite mosaic work and bas-reliefs and six twisting columns sitting on lion pedestals. An eagle grandly tops the inlaid marble lectern.
A chapel to the left of the apse is dedicated to Saint Pantaleone, a physician beheaded in the 3rd century in Nicomedia. Every July 27 devout believers gather in hope of witnessing a miracle (similar to that of San Gennaro in Naples), in which the saint's blood, collected in a vial and set out on an inlaid marble altar, appears to liquefy and come to a boil. In the crypt is the Museo del Duomo, which displays treasures from about the 13th century, during the reign of Frederick II of Sicily.
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