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Heidelberg is a 15-minute drive (10 km [6 miles]) on A-656 from Mannheim, a major junction of the autobahn system. The Burgenstrasse (Route B-37) follows the north bank of the Neckar River from Heidelberg to Mosbach, from which it continues south to Heilbronn as B-27, the road parallel to and predating the autobahn (A-81). B-27 still leads to Stuttgart and Tübingen.

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