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Guided one-day bus tours from Prague are available from several companies to the larger spa towns.
Martin Tours. One of the country's larger tour operators, Martin Tours offers regular trips to Karlovy Vary and the brewery in Plzeň for 1,350 Kč and 1,200 Kč each. Lunch and swimming in a thermal pool on the Karlovy Vary trip is extra. The Plzeň trip includes beer tasting. www.martintour.cz.
Tip Top Travel. Tip Top Travel offers a combined Karlovy Vary–Mariánské Lázně tour for 2,100 Kč. The tour lasts about 10 hours and the price includes a pickup at your hotel. www.tiptoptravel.cz.