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In general, Fez and Meknès are safe cities. In Fez—less in Meknès—pickpocketing and unwanted hassling from hustlers and false guides will be the biggest concern. Harassment from those offering to be tour guides or drivers is best avoided by smiling and firmly saying "no thank you," preferably in Arabic or French; never become visibly agitated, as it could exacerbate the situation.
You can safely explore the Fez medina during the day, but avoid quieter areas. If you get off-track, turn around and head back to more populated areas. If you are followed, enter a store, hotel, restaurant, or café and ask for help. Avoid any contact with solicitors. At night, barely lit passageways and dark medina alleys are intimidating.
From December through January, heavy snowfall may cover Middle Atlas roads; however, the snow-removal system in places such as the Azrou Cedar Forest are relatively good with cleared driving routes. More remote roads (marked in white on the Michelin map of Morocco) will be difficult to access or completely closed in snowy conditions. Driving off-road or to natural sites such as the Cascades d'Ouzoud in winter when snowfall can be significant is not advised.