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Your thoughts - Driving from Downtown San Francisco to Fresno

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This will be on a Tuesday in October.
I will be able to leave downtown San Francisco around 730pm.
3 routes are suggested by Google:
1. 580E to 99S
2. 580E to 5S to 152E to 99S
3. 101S to 152E to 99S
They all claim to have approx the same drive time of 3.5 hours.

I really dread this long drive after dark.
Can anyone offer up any suggestions or guidance on this trip... other than cancelling or taking a plane :)
Thanks so much!

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