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Which cross-country route, I-40 or I-80?

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If you had to drive from Louisville, Kentucky to San Francisco in January, which route would you take? I won't be stopping to see anything really, this trip is more about efficiency.

Generally, my choices seem to be I-80 or I-40, with some less important differences at the beginning of the trip, around St. Louis / Kansas City, or Nashville / Little Rock. My main concern is, is I-80 generally too snowy / windy / wintery to drive all the way across it in January? Specifically through Nebraska, Wyoming, Utah, and Nevada?

Either way, I'm NOT taking I-70 through Denver -- that seems like the worst choice.

I'm open to suggestions. Just not sure what these areas of the country (and their interstate conditions) are like in January. (Specific route options detailed below for those interested.) Thanks, all!

I-64 to I-70 to I-29 to I-80:
Louisville, KY
St. Louis, MO
Kansas City
Lincoln, NE
Cheyenne, WY
SLC, UT
Elko, NV
Reno, NV
Sacramento, CA
SF

or

I-64 to I-44 to I-40 to I-5:
Louisville, KY
St. Louis, MO
Tulsa, OK
OK City, OK
Amarillo, TX
Albuquerque, NM
Flagstaff, AZ
SF, CA

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