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Where to stay in San Francisco

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Am totally unfamliar with San Francisco. Have the opportunity for a quick getaway with my husband sans children February 23-27. I am trying to make plans. I know there are several areas/neighborhoods. We would like to be located where we could get around fairly easily. Is this best done by cable car? Taxi? Other? Which area would be a good central place? Hotels ideas? Would like to keep it around $200/night?

Want to check out the Wharf, Alcatraz, etc. Is a day trip to Sonoma or Napa doable?

Thanks for all your help.

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