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Suggestions for quickest driving route from Knoxville to Toronto area?

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I'm 'on call' for when my daughter gives birth to my grandson in mid-Sept. I live 90 mi south of Knoxville, TN, and wondered if there was a "best route" for making good time driving to Oakville, Ontario. (Don't want to go the Detroit-route.) I'll stay overnight somewhere along the way, making it a 2-day trip. Thanks!

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