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St Louis... hotels/areas to avoid?

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We (me, my husband, and elderly parents) will be staying in St Louis for a night in March on a road trip vacation to Nashville, then on to GA, SC, NC. We'll want to stay more on the perimeter of St Louis to avoid rush hour traffic. I'm wondering about the following St Louis areas....are they safe and which would be a better choice for convenience and decent hotels?

St Louis West
Westport Maryland Heights
Fairview Heights, O'Fallon, Collinsville

Any insight provided would be appreciated. Thanks!

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