I am currently looking at doing a solo trip from New Orleans to Atlanta in March 2013 and will have about 2 weeks. I am really keen to do an organised tour as I have done Contiki before and loved it however all tours in Southern US dont seem to run in March. If anyone can inform me differently please let me know.
In saying that if I have to "go it alone" I would love some advice. 
My thoughts of the trip so far would be start in New Orleans then to Jackson, then to Memphis, then to Nashville, then to Atlanta.
I am not sure if I am missing anything nearby that is a standout but if I allow for about 2 -3 nights at each destination I think I should be able to cover the "best" of that region.
Just wondering if anyone has any ideas that are must do's to fill that sort of itinerary.
Thanks
Solo Road Trip/Tour New Orleans to Atlanta
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You can tour solo easily. Stay in the FQ in NOLA at Place D Armes, St. Marie, Monteleone, Provincial, Le Marais, Royal Sonesta, Royal Orleans or Iberville Suites. Take # 61 N to Natchez, MS for a night or two then head on up # 61 to Vicksburg for a night. Stay at Anchuca in an antebellum home and visit the National Military Park. Spend a night in Clarksdale, MS at Shack Up Inn and visit Ground Zero Blues Club. Spend a couple of nights downtown in Memphis near Beale Street and walk to all the attractions. Head E to Nashville and stay downtown near the clubs and bars. Then head to Atlanta. Enjoy your trip.
VISIT THE DELTA..........
http://www.visitthedelta.com/
If you were willing to drop Nashville from the trip, you could hit all of the rest by using Amtrak and not have to worry about a big drop off fee on a rental car.
Fly to Memphis. See Memphis and perhaps rent a car to drive to Nashville and back to Memphis. Turn in the car and take the "City of New Orleans" to Jackson (4 hours all daylight).
Spend 24 hours in Jackson and catch the next CONO into New Orleans (another 4 hours daylight). Spend at least 2 days in New Orleans before getting on the Amtrak Crescent. You have several choices on where to get off the Crescent between NOL and Atlanta. Perhaps Meridian Mississippi or Birmingham AL.