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Small towns to see between Bryson City NC and Charleston SC?

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Hi all

I'm almost done planning a 2 week road trip from Asheville to New Orleans, via Charleston...from London UK!

The only thing I'm missing on the itinerary is:

1. Any cute, sleepy, typical Southern small towns that we can visit for a lunch stop or short detour, between Bryson City and Charleston?
We've heard that the Interstate drive is pretty boring, and want to use this day to see typical Southern life. Or if you can recommend a route then please do.

2. As per the above, this time between Savannah and Panama City, FL?

I.e something to break up the long drives. Interested in possibly going peach picking, a hot springs, wandering pretty town squares, or any quirky 'roadside America' ideas.

Thanks

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