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San Francisco to Palm Springs road trip

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My husband and I are driving to Palm Springs from San Francisco. Do any of you have suggestions for the most scenic route and where to stop for the night - we'll plan to take 2.5 days staying overnight in 2 places. We are also driving back - PS to SF so what we miss on the way there we can visit on the way back. We are Californians and have already made many many visits to places like Carmel and Monterey - so that route along the coast doesn't appeal.
Thanks for any ideas - places to lay our heads the 2 nights on the road.
Janet
BTW - we leave next week - Feb 6, 2013....winter in the mountains! We do not have chains for snow!

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