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San Francisco to Bend

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Hi
We are a family of 5, 3 adults and 2 teens, travelling from SF to Portland OR. We have arranged to meet up with family in Bend OR and are looking for the best route and place to overnight between SF and Bend. We can't choose between Klamath Falls option or Medford / Grants Pass option. Any advise would be appreciated.

If the I5 is the best option, should be overnight in Grants Pass or Medford? Can we cross country from I5 to Crater Lake and continue up the 97 to Bend

Tks in advance
Suz

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