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San Francisco Neighborhood Advice

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Next May we will make our first visit to San Francisco as tourists. We will rent an apartment thru VRBO or equivalent for 3-4 days before renting a car and driving to Yosemite. We are looking for advice on a San Francisco neighborhood or area on which to focus our search for accommodation. Our interests include museums, interesting walks (views, history, architecture), water views and/or proximity to water. While in the city, we will not have a car. We are very active seniors. Thanks in advance for your help.

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