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San Francisco area - what would you do?

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I'm just starting to research a possible trip to San Francisco and the general area, likely in May (I know it's a little bit late, but I need to get out of town!). I've never been to California at all except for San Diego last year. I'd be going with a female friend, both in our early 30s, so a girls' getaway kind of trip (we're not that into spas, though)!

Since I've never been to the area, I'm having a hard time putting together even a vague realistic itinerary. Based on what I've heard, I'd be interested in...
- San Francisco itself, of course
- Monterey/Carmel/Big Sur for scenery
- Napa/Sonoma, although I don't drink an awful lot and my friend barely drinks at all, so I'm not sure if this would be the best trip for this
- Yosemite - I know this is further away, and getting reservations anywhere in/near the park could be tough, but if even a long day trip is feasible I'd love to see sequoias, waterfalls, rock formations, and/or do an easy/moderate hike

We would probably have about a week. We like to eat, but not generally fine dining - I'm just as happy with an amazing taco or great cafe as I would be with a fancy restaurant (another reason I'm not sure about Napa). Last year I drove through Palm Springs (en route to Joshua Tree) under the impression it was a happening fancy shopping/resort area, only to realize the town itself is... underwhelming, especially to a 30-year-old! Or maybe it's a terrible idea to try to go out to Yosemite, I don't know. So I'm looking to avoid that sort of situation. Any general thoughts you have would be great!

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